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I love Isidora! (although I like Isadora spelling too). It's a bit long for everyday though, so it probably should have a nickname. I think Isidora "Isis" would be cool, although I don't know if they'd consider Isis to OTT to be a nickname. Otherwise Isa or Dora would work. I agree that Izzy is overdone.
I think Jethro could go with Isidora (although I don't really have any associations with either).