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I personally think that far more people are going to associate Wyeth with the pharmaceutical company of the same name, rather than with the painter Andrew Wyeth. Especially in the United States, which is the most medicated country in the world. As such, if you live in the United States, you might want to use Wyeth as a middle name instead. The pharmaceutical company no longer exists (as of 2009) and therefore a child with the name is unlikely to be bullied for his name by his peers, but adults might still make the occasional comments about it (not necessarily mean-spirited) to him *and* you for some time to come (as I expect that the pharmaceutical company will remain in the collective memory for a while).

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https://en.wikipedia.org/wiki/Wyeth

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That aside, I personally don't care for the look of Wyeth. It kind of looks like a femininisation of Wyatt, because I feel like -eth is more commonly seen in feminine names (mainly thinking of Gwyneth and similar Welsh names here). As a result, I prefer Wyatt for a boy, because it looks sturdier and is also simply already fully established as a boy's name. But if you're absolutely set on using Wyeth, then it's probably best to pair it with a name that is not only more traditional, but also more firmly masculine. That way, there would be a nice balance between the slight unusualness and femininity of Wyeth and the normalcy and masculinity of the other name.

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"How do you pick up the threads of an old life? How do you go on... when in your heart you begin to understand... there is no going back? There are some things that time cannot mend... some hurts that go too deep... that have taken hold." ~ Frodo Baggins