It has occasionally been used as an English given name since the 16th century. It was moderately popular in the 1940s, but had a more notable upswing in the early 2000s. This may have been inspired by the Spanish actress Penélope Cruz (1974-), who gained prominence in English-language movies at that time. It was already rapidly rising when celebrities Kourtney Kardashian and Scott Disick gave it to their baby daughter in 2012.
As a given name, it has found occasional usage in the English-speaking world from the late 19th century onwards.
Due to the saint's popularity, the name came into general use in medieval Europe, especially in Spain and France. It was also borne by a 16th-century king of Portugal who died in a crusade against Morocco.
This was a common name in classical Greece, and, due to both the saints who carried it and the favourable meaning, it came into general use in the Christian world, being especially popular among Eastern Christians. It was however rare in Britain before the 19th century. Famous bearers include three tsars of Russia (in the Russian form Fyodor) and American president Theodore Roosevelt (1858-1919).