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I think it works as a nickname for a character or real person. It's a bit of a stretch, but it could work as a nickname for Antiope. Maybe Theophila or Tiffany / Tiphanie. If some Elizabeths can go by Biz or Diz and Edwards can go by Ned, I think that a Tiffany could go by Tippy instead of Tiffy. Tiffany is NMS, but I think it could work for certain characters depending on their personalities and such.

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Antigone "Tiggy" is neat.

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Another name that I think is neat for a character is Zipporah "Zippy."