Type River Usage English, Ancient Roman, Ancient Greek Scripts Εὐφράτης(Ancient Greek) Meaning & History From Greek Εὐφράτης (Euphrates), the name of a river in Mesopotamia. It is derived from Old Persian 𐎢𐎳𐎼𐎠𐎬𐎢 (Ufratu), itself from Elamite or Sumerian, of uncertain meaning.