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Cuzco(Political Subdivision & Settlement)Inca (Hispanicized), Quechua (Hispanicized), Spanish (Archaic) Traditional spelling of Cusco, a city in Peru which was the capital of the Inca Empire. Cusco is the Hispanicized form of Quechua Qusqu meaning "rock, boundary stone; heap of earth and stones; nucleus; navel; bed, dry bed of a lake".